Scientist I, Immune Evasion

The Role Scientist I, Immune Evasion. Advancing Dyno’s immune evasion capabilities by developing and executing innovative assay strategies that enable the discovery and clinical readiness of next-generation capsids. Job Type: Full Time, onsite Location: Watertown, MA How You Will Contribute As a Scientist I, you will independently lead and evolve Dyno’s high-throughput immune evasion assay platform, driving antibody evasion studies that support CNS and Muscle capsid discovery programs and partnering cross-functionally to shape experimental strategy and address technical gaps. You will also help expand the team’s immune evasion capabilities beyond pre-existing antibodies to emerging clinical readiness challenges, including re-dosing, T-cell responses, complement activation, and innate immunity. At Dyno, every role is mission-driven. Whether in science, engineering, operations, or business, each AAViator contributes to solving some of the most complex challenges in genetic medicine. Responsibilities: Independently execute and support high-throughput immune evasion (IE) assays, including antibody neutralization and total antibody immunoprecipitation (tAb IP) workflows, to ensure uninterrupted support for CNS and Muscle capsid discovery programs. Own the day-to-day operation, optimization, and troubleshooting of immune evasion assay platforms, iteratively refining workflows and developing new assay formats in response to evolving program needs and emerging data. Analyze, interpret, and communicate immune evasion screening data to cross-functional stakeholders, helping inform capsid selection and discovery strategy. Contribute to the expansion of Dyno’s immune evasion capabilities beyond antibody neutralization by reviewing literature, proposing experimental approaches, and conducting feasibility studies related to re-dosing, T-cell responses, complement activation, and innate immunity. Partner closely with Immune Evasion, CNS, Muscle, and in vivo teams to identify technical gaps, improve assay throughput and robustness, and accelerate progress toward clinically ready capsids. Support the long-term development of internal immune evasion discovery capabilities, including high-throughput library cloning and production workflows, to increase team self-sufficiency and create additional bandwidth for receptor-targeted capsid discovery efforts. Basic qualifications Ph.D. (or equivalent experience) in Immunology, Cell/Molecular Biology, or a closely related discipline, with deep understanding of immune mechanisms relevant to gene therapy (e.g., humoral immunity, antigen presentation, immune cell activation). Hands-on experience with immunological assays (e.g., immunoprecipitation, ELISA, neutralization, ELISPOT assays) and molecular biology techniques (qPCR, flow cytometry, NGS library prep, NGS-based experimental design). Prior experience with antibody biology and/or adaptive immune responses (e.g., B-cell/T-cell biology, serology, neutralization mechanisms). This is directly relevant to the team’s core mandate. Strong experimental design skills and the ability to independently troubleshoot complex, multi-step assay workflows. Ability to critically evaluate scientific literature and translate findings into actionable experimental hypotheses. Foundational knowledge of statistical methods for data analysis and hypothesis testing. Effective scientific communicator—able to present results clearly to both technical and cross-functional audiences. Preferred qualifications Familiarity with in vivo models of immune response or experience interpreting in vivo immunogenicity data in the context of gene therapy or biologics. Prior experience designing and working with high-throughput libraries (DNA/molecular) or large-scale screening workflows. Working knowledge of Python or R for data analysis; comfort with large datasets from NGS or high-throughput screening. Exposure to AAV biology, gene therapy, or viral vector engineering. The Company At Dyno