Senior Computational Biologist

Are you ready to own the analysis, predictive modeling and interpretation of large-scale perturbation single-cell transcriptomic screens, turning high-dimensional, complex gene expression state changes into clear biological conclusions that drive therapeutic decisions in cardio-renal-metabolic disease? Large-scale transcriptomic data is at the heart of Gordian’s discovery efforts, and the company will succeed based on our ability to accurately predict physiological changes in disease using single cell gene expression as a readout. In this role, you’ll help ensure our screening and validation decisions are grounded in rigorous, transparent and state-of-the-art analyses, enabling us to confidently prioritize the best targets and interventions. The Destination: Gordian Biotechnology is a therapeutics company whose mission is to cure age-related disease and wake up every morning more capable than the day before. Traditional ex vivo screening methods have failed to produce effective treatments, as age-related diseases have complex causes that include interactions with the aged environment. To address this problem, Gordian’s platform is the first and only to enable pooled in vivo tests at scale, across different species of diseased animals reflecting patient profiles. We are able to deliver and test hundreds of therapeutics in individual animals, and scale efficacy testing to rapidly prioritize targets and interventions with a clear path toward development (more info on our website ). We are running this discovery engine to ensure an abundance of therapeutic hypotheses can be tested for complex diseases, eventually mapping out the effects of every druggable target across many diseases, and advancing programs both internally and through collaborations with external partners. By working across related sets of indications, we can identify medicines with impacts on age-related multimorbidity. The Journey: Our mission is audacious, and the path will be full of both challenges and excitement. Two things characterize the Gordian experience: 1) We work as a team, with ownership in our own roles and trust in each other. 2) We strive for extraordinary outcomes, and in doing so grow our skills and capability. Team – Relying on each other begins with transparency. We set clear goals, visibly connecting individuals and teams to our company objectives. This empowers each of us to make autonomous decisions about our work, knowing how they will affect the bigger picture. Our communication happens out in the open. We give and receive feedback from a perspective of helping each other grow, share mistakes, and ask for help. Extraordinary – Every day, we ask ourselves ‘How could this process/outcome be even better?’. Knowing our overall mission, we do what we think helps us make the most progress, without asking for permission. We don’t shy away from big challenges or unknown territory, but find a way to excel. Our colleagues are amazing, both at what they do and as people. They inspire us to keep up, to not let them down, and be inspiring in return. Like any cutting-edge research environment, Gordian doesn't believe in a standard 9 to 5 day. We set ambitious project goals and support each other to meet them, while maintaining the balance individuals need to thrive and achieve excellence. Our team is geared towards helping each other out and maintaining a culture of intellectual and social fun. We like getting things done and keep standing meetings to a minimum. We have an unlimited vacation policy, not including major holidays. We unwind with weekly team lunches, and support each others’ projects both experimentally and by ‘pre-mortem’ meetings to discuss possible failure modes and experimental design. If this environment sounds appealing, help us bring it to life. We are at an exciting inflection point: applying our technology to create comprehensive atlases of therapeutic targets across multiple diseases, partnering for financial and intellectual su