Director, Business & Operations – US Commercial

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Director, Business & Operations – US Affiliate will serve as a key strategic and operational partner to the SVP, Head of US Affiliate, supporting the effectiveness, execution, and scalability of the US Affiliate organization. This role will provide operational leadership and continuity across the function, enabling the US Affiliate & Commercial Leadership Team to remain focused on the highest‑impact priorities as Dyne builds and grows its US presence. The Director will be responsible for business operations across the US Affiliate, including budget ownership and financial planning, vendor and contract management, operating rhythm and governance, and the execution of function‑wide initiatives. Acting as a connective hub across Commercial, Medical, Finance, Legal, HR, and other G&A partners, this leader will translate strategic priorities into well‑structured plans, drive execution, and ensure visibility into progress, risks, and resource needs. The ideal candidate is highly organized, proactive, and comfortable operating in a fast‑paced, evolving environment. They bring strong judgment, executive presence, and the ability to influence without authority, paired with a hands‑on approach to getting work done. This role is based in Waltham, MA. Primary Responsibilities Include: Strategic & Operational Partnership Serve as a trusted thought partner to the SVP, Head of US Affiliate, translating affiliate strategy and priorities into clear, actionable, and measurable operating plans as Dyne prepares for its first U.S. product launch. Support the US Affiliate Leadership Team with structured problem solving, prioritization, and follow‑through across key initiatives. Anticipate organizational needs and proactively bring recommendations, options, and solutions to leadership. Business Operations & Operating Rhythm Establish and manage the operating rhythm for the US Affiliate, including leadership meetings, business reviews, planning cycles, and governance forums. Drive clarity on goals, ownership, timelines, and success metrics across affiliate initiatives. Develop and maintain dashboards and tracking tools that provide transparency into performance, risks, dependencies, and decision points. Budget, Financial Planning & Resource Management Support development and management of the US Affiliate budget in close partnership with Finance, including annual planning, forecasting, tracking, and variance management. Support headcount planning, resource allocation, and investment prioritization to ensure alignment with affiliate and enterprise objectives. Prepare budget materials, analyses, and recommendations for affiliate leadership and enterprise review forums. Cross‑Functional & Enterprise Initiatives Lead and coordinate high‑priority, function‑wide and cross‑functional initiatives impacting the US Affiliate. Act as a central point of integration between the US Affiliate and partner functions to ensure alignment and execution. Track initiative progress, identify risks, and escalate issues with proposed solutions. Leadership Enablement & Execution Drive coordination across HQ and field‑based roles spanning Commercial, Medical, and partner functions to maintain momentum and alignment on priority initiatives. Design and manage the US Affiliate “Cadence of