Scientist II or Senior Scientist, Discovery Proteomics

Who we are: Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn . How we work: PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines. COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine. BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard. How you’ll make an impact: Working closely with program teams towards addressing key biology and chemistry questions Develop and optimize sample preparation and mass spectrometry methods for deep quantitative analysis of cell and tissue total proteomes as well as post-translational modifications. Perform maintenance, quality control and troubleshooting of instruments, including HPLCs and mass spectrometers Establish robust nLC-MS-based data acquisition and analysis workflows Provide documentation, analysis, interpretation and presentation of experimental data in a clear and concise manner Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner. Stay up to date on proteomics methods and technologies Proactively recognize and solve technical and scientific issues to ensure high quality proteomics data is generated for the progression of drug discovery projects. Skills and experience you’ll bring: PhD in Biochemistry, Biology, Chemical Biology, or a related discipline, with 3+ years of quantitative mass spectrometry-based proteomics experience, or 7+ years of industry experience in proteomics. Extensive hands-on experience in proteomics is required including: Demonstrated ability to independently troubleshoot, analyze, and interpret proteomics data with attention to detail, to recommend and execute next steps. High level of proficiency in a variety of quantitative proteomics techniques including DIA, label-free quantification and peptide fragmentation methods. Maintaining and troubleshooting HPLCs and mass spectrometers. Developing methods and performing nano LC-MS/MS experiments using Orbitrap Astral or Orbitrap Exploris 480 mass spectrometers. Experience in computational analysis and downstream statistical analysis software packages, such as DIANN, Perseus, R or Python, to address key program questions. Ability to work in an agile, fast-paced, team-oriented environment. Lead from the lab for activities include hit validation, lead optimization, target validation, and small molecule mechanism of action studies Experience with PTM analysis (phosphorylation and ubiquitination), protein interaction analysis, and targeted proteomics are a plus. Experience in low abundance protein isolation from complex biological samples including cells, tissue and biofluids and affinity enrichment to selectively enrich sub-proteomes and experience with automation and liquid handling systems are a plus. Experience in mapping protein-protein interactions by mass spectrometry with pulldown approaches, proximity labeling and XL-MS are a plus Tissue culture experience with