Endpoint Systems Engineer

Who we are: Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn . How we work: PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines. COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine. BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard. How you’ll make an impact: Kymera Therapeutics is seeking a highly capable Desktop Engineer to serve as the L3 escalation point for endpoint and user support within our hybrid Microsoft environment. This role is central to maintaining a secure, reliable, and well-managed computing experience for employees across the organization. The engineer will handle advanced troubleshooting, modern device management with Intune, identity and authentication support, and deep Windows client diagnostics. The ideal candidate brings a cloud-first mindset, with the judgment and experience to operate effectively in an environment where cloud and on-premises systems still coexist. They should understand the realities and constraints of a hybrid infrastructure while actively helping the organization move toward more modern, cloud-aligned practices. This role requires strong technical instincts, the ability to collaborate across Infrastructure, Cybersecurity, and Applications teams, and a commitment to improving the stability, security, and effectiveness of the end-user computing environment. Endpoint Management & Intune Support Package, deploy, and maintain Win32 applications through Microsoft Intune Build and update remediation scripts, configuration profiles, and compliance policies Troubleshoot Autopilot enrollments, ESP issues, and device identity inconsistencies Ensure consistent device hygiene, lifecycle management, and operational readiness Identity & Access Management Troubleshoot hybrid identity issues involving Entra ID, Azure AD Connect, and device join states Support user and device identity lifecycle processes Resolve authentication failures, directory sync issues, and group-based access concerns Contribute to identity-related troubleshooting improvements and best practices Microsoft 365 Support & Escalation Provide advanced troubleshooting for Exchange Online, Teams, SharePoint, and OneDrive Diagnose and resolve mail flow problems, permission conflicts, and policy inconsistencies Support configuration and lifecycle management of M365 Groups Assist with cross-service issues affecting collaboration and user productivity Windows Client Engineering Diagnose OS, driver, performance, profile, and Windows Update issues using advanced tools Analyze event logs and system telemetry to determine root causes Identify recurring endpoint issues and recommend corrective actions Support imaging and Autopilot health by addressing underlying system issues Scripting & Automation Develop and maintain PowerShell scripts for support, remediation, and automation Use JSON and basic Graph API calls when necessary Identify opportunities to reduce manual work and improve consistency Security & Co