Staff Mechanical Engineer, Consumables

What if your next design project wasn't just on new technology like a phone or domestic appliance but actually helped make cancer a thing of the past? At 10x Genomics, our mission is to accelerate the mastery of biology to advance human health. But that progress doesn't happen in a vacuum—it is driven by new technologies and the people with the courage to build them. We are moving with incredible urgency. We recently celebrated a massive milestone with the official unveiling of our newest innovation: Atera . This system is a prime example of how we use first principles to make the impossible possible, bringing high-impact single cell analysis to more researchers than ever before. To keep this momentum going, we are looking for a Staff Mechanical Engineer, Consumables who isn't afraid of "difficult." This isn't just about CAD tools and validation testing; it’s about interdisciplinary collaboration and solving the intricate challenges that stand between us and the next medical breakthrough. We believe that "WE" is more important than "ME." You’ll work alongside world-class scientists and manufacturing experts to ensure our consumables integrate perfectly with the biological workflows that are changing the world. Whether you are optimizing high-volume injection molding or leading a design from concept to commercialization, your work will be the foundation for the next generation of cures. If you are a doer who loves a challenge and wants to build a lasting legacy, you’ll find your home here. We don't just follow the path set by others—we forge our own. What you will be doing 1. Strategic Design & Technical Leadership High-Precision Consumables: Lead the architecture and design of complex biotech consumables, focusing on Injection Molded (IM) plastics , over-molding, LSR and assembly techniques (ultrasonic welding, laser bonding). Fluidic Integration: Drive the development of fluidic and microfluidic systems by consulting with fluidic SMEs, ensuring seamless integration between consumable cartridges and permanent instrument hardware. Advanced Simulation: Utilize FEA, tolerance analysis, and CFD to predict part behavior and ensure robust performance under laboratory operating conditions. Regulatory Excellence: Design for compliance with ISO 13485, FDA 21 CFR Part 820 as well as RUO . Contribute to the creation of Design History Files (DHF). 2. End-to-End Project Ownership Concept to production: Take full ownership of critical subsystems from "napkin sketch" through high-volume manufacturing (HVM). DFX Leadership: Champion Design for Manufacturing (DFM) and Design for Assembly (DFA) , working closely with toolmakers and CMOs to ensure tool designs and strategies are optimized. Vendor Management: Act as the primary technical point of contact for external molding partners and material suppliers, ensuring quality and performance standards are met. 3. Innovation & Problem Solving IP Generation: Identify and pursue patentable innovations in fluid handling, sealing technologies, and consumable-to-instrument interfaces. Root Cause Analysis: Lead complex failure analysis (FEA, SEM, etc.) for plastic components, identifying issues like creep, stress cracking, or biocompatibility failures and implementing permanent corrective actions. 4. Leadership & Mentorship Technical Mentorship: Directly mentor junior Engineers, fostering a culture of rigorous engineering discipline and creative problem-solving. Cross-Functional Bridge: Serve as the "mechanical voice" in rooms full of Biologists, Chemists, and Software Engineers to ensure the hardware meets the underlying science. Minimum Requirements Education: BS/MS in Mechanical Engineering. Experience: 10+ years of experience in mechanical design, with at least 5 years specifically in medical devices or biotech consumables. Plastics Expertise: Deep knowledge of thermoplastic resins (COC, COP, PC, PP), elastomers (TPE/TPU), and the nuances of high-volume injection molding. Tooling/Equipment: Experience