Director, Health Economics & Outcomes Research (HEOR)

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered. *AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making. Summary: Vaxcyte is seeking a Director, Health Economics & Outcomes Research (HEOR) to establish and lead the company’s health economic strategy across the vaccine lifecycle, with initial focus on adult pneumococcal programs. This strategic leadership role will be responsible for developing and executing global health economic models to support payer value propositions, immunization policy engagement, reimbursement strategy, and external stakeholder communications. This role will focus specifically on health economic modeling and payer value strategy. Observational real-world evidence and epidemiology studies will be led by the Epidemiology & Real-World Evidence function. The Director, HEOR will work in close collaboration with RWE and Epidemiology colleagues to ensure economic models are grounded in robust disease burden, vaccine effectiveness, and coverage assumptions. As Vaxcyte advances toward commercialization, this role will partner closely with Market Access colleagues, who will lead pricing and contracting strategy. The Director, HEOR will provide the analytic foundation and economic evidence required to inform pricing strategy, payer engagement, and health technology assessment discussions. Essential Functions: Health Economic Strategy & Leadership Develop and lead Vaxcyte’s HEOR strategy across early development, launch planning, and lifecycle management. Define the economic evidence generation plan required to support payer access and policy recommendations. Ensure health economic considerations are incorporated early into development planning. Health Economic Modeling Lead development of cost-effectiveness, budget impact, and population health models for adult and pediatric vaccine programs. Design and oversee decision-analytic models (e.g., Markov models, microsimulation models, dynamic transmission models as appropriate). Establish modeling assumptions grounded in epidemiologic, clinical, and real-world data. Ensure all models are scientifically rigorous, transparent, and defensible in policy and payer environments. Value Communication & Policy Support Translate health economic findings into clear, compelling value narratives for internal leadership and external stakeholders. Support development of global value dossiers, AMCP dossiers, and materials for payer engagement. Contribute to peer-reviewed publications and scientific congress presentations. Cross-Functional Partnership Partner closely with Epidemiology & RWE to integrate disease burden and vaccine effectiveness assumptions into economic models. Collaborate with Clinical Development, Regulatory, Medical Affairs, and Market Access teams to align value strategy. Support consistent, aligned value messaging across stak