Medical Director - Skin/IO

Location: Remote with ~40% domestic and international travel Shape the future of cancer care as a Medical Director, Skin/IO at Natera. In this strategic leadership role, you will provide medical expertise and scientific leadership across Natera’s oncology portfolio, with a focus on melanoma, cutaneous malignancies, and immunotherapy applications across solid tumors. You will collaborate with cross-functional teams in research, development, medical affairs, and commercial functions to ensure the scientific integrity and clinical adoption of Natera’s oncology testing solutions. Primary Responsibilities: Clinical Adoption: Lead the clinical strategy and evidence generation for melanoma, non-melanoma skin cancers, and pan-tumor immunotherapy indications. Partner closely with clinical development, medical affairs, and commercial teams to translate emerging evidence into meaningful clinical practice applications. Collaborate with key opinion leaders (KOLs), cooperative groups, and academic investigators to validate and expand clinical use cases for ctDNA-based diagnostics in immuno-oncology. Provide field-facing education and strategic guidance to healthcare providers, payers, and advocacy organizations on clinical utility, interpretation, and impact of MRD and response monitoring in immune-treated populations. Identify and address barriers to adoption by aligning evidence generation, messaging, and stakeholder engagement with evolving standards of care and health system needs. Medical Education and Communication: Serve as the medical and scientific spokesperson for skin and immuno-oncology programs, communicating clinical utility, study data, and product value to external experts and stakeholders. Partner with commercial teams to develop educational resources, medical content, and scientific training for healthcare providers and internal teams. Provide scientific leadership during advisory boards, symposia, and investigator meetings. Representation and Advocacy: Represent Natera at national and international oncology and immunotherapy conferences, fostering relationships with key opinion leaders in melanoma and IO. Promote a culture of scientific rigor and innovation within the medical affairs and R&D organizations. Research and Development: Collaborate on clinical trial design, data analysis, and publication strategy related to ctDNA applications in melanoma and other immune-responsive solid tumors. Identify and cultivate academic and cooperative group partnerships to advance clinical validation and translational research in skin and pan-tumor immuno-oncology. Key Skill Sets / Responsibilities: Skin and Immuno-Oncology Expertise: Deep clinical knowledge of melanoma and cutaneous oncology, including evolving standards of care, targeted therapy, and checkpoint inhibitor use. Expertise in immunotherapy mechanisms, response kinetics, and biomarker development across multiple solid tumor types. Provide expert medical guidance on immunotherapy-specific diagnostic development and clinical implementation. Comprehensive Oncology Knowledge: Ability to engage across tumor types to support Natera’s broad oncology portfolio. Maintain awareness of emerging trends in liquid biopsy, precision medicine, and immune response monitoring. Cross-Disciplinary Collaboration: Work collaboratively with research, development, commercial, and medical affairs to align medical strategy with business objectives. Partner with regulatory and clinical operations teams to ensure compliance, data quality, and clinical relevance. Qualifications: MD. or D.O. degree with board certification in Medical Oncology (required). At least 5 years of experience in oncology, with clinical or research experience in melanoma, skin cancers, or immunotherapy (preferred). Strong publication or clinical trial background in immuno-oncology or translational oncology research (preferred). Associate or full Medical Director designation commensurate with experience. Knowledge, Skills, and