Senior Research Associate

POSITION SUMMARY: Join Natera’s R&D team as a Senior Research Associate specializing in Oncology Assay Development. You will design, execute, and optimize next-generation sequencing (NGS) and cell-free DNA (cfDNA) workflows to build liquid biopsy tests that directly impact patient care. Every sample represents a real person, and your analytical rigor will ensure the highest standards for clinical implementation. PRIMARY RESPONSIBILITIES: Design, plan, and execute experiments to support the development, optimization, and validation of oncology assays Independently execute experimental workflows, including cfDNA extraction, library preparation, target enrichment, and sequencing Develop and pressure-test new methods to improve the performance and precision of our clinical assays Analyze and interpret experimental data using appropriate statistical and analytical tools Maintain precise documentation in electronic laboratory notebooks, protocols, study plans, and technical reports Think team by partnering directly with bioinformatics, biostatistics, automation engineering, software, and operations teams without translation layers Communicate findings clearly through presentations and technical reports, ensuring unvarnished, data-backed updates Support technology transfer to Clinical Laboratory Improvement Amendments (CLIA) regulated operations, driving protocol improvements, training, and troubleshooting Troubleshoot assays by identifying root causes and implementing data-driven improvements Manage multiple projects with pace and precision, prioritizing tasks based on data to meet established milestones Handle protected health information (PHI) in paper and electronic formats as required to perform duties Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training QUALIFICATIONS: B.S. degree in molecular biology, a related field, or equivalent Minimum of 3 to 4 years of industry experience in an assay development department KNOWLEDGE, SKILLS, AND ABILITIES: Direct hands-on experience with nucleic acid techniques, including DNA manipulation, PCR, qPCR, and DNA quantitation and analysis tools such as LabChip, BioAnalyzer, and Tapestation Experience with Next Generation Sequencing (NGS) workflows, spanning library preparation, target enrichment, sequencing platforms, and associated quality control metrics Experience running automation platforms, such as Hamilton, Bravo, BioMek, or KingFisher Ability to interpret NGS data outputs, including Q30 scores, pass filter rates, coverage, on-target rates, and error rates Ability to manage multiple experiments and priorities simultaneously while operating with operational rigor Apply scientific literature and data to pressure-test assumptions and drive continuous improvement Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and skills considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $87,300 — $109,100 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you