Scientist, Research (Epigenomics)

The Molecular Biology Research team at Natera is looking for a highly motivated Scientist to join our group focused on developing and advancing Natera's oncology product portfolio. In this role, you will apply your expertise in epigenomics to develop novel cell-free DNA diagnostic assays for cancer detection and disease monitoring. We are looking for a meticulous and dedicated candidate with hands-on laboratory experience in epigenetic assay development who can work effectively in a fast-paced environment to ensure the highest quality clinical assays are developed and launched for our patients. The right candidate maintains broad knowledge of state-of-the-art principles in epigenomics and molecular biology with an understanding of their applicability to oncology research. PRIMARY RESPONSIBILITIES: Independently plan and execute experiments of moderate complexity to develop next-generation automated nucleic acid based diagnostic workflows Design and optimize assays leveraging epigenetic signals (e.g., methylation) from cell-free DNA for clinical applications Perform basic data analysis (e.g., JMP, R, Python, Excel), write study protocols, and SOPs Collaborate cross-functionally with other teams, including data scientists and bioinformaticians Generate reports and presentations to communicate findings directly to peers and management Contribute insights towards experimental findings and troubleshoot laboratory processes and protocols. QUALIFICATIONS: Degree in molecular biology, epigenomics, biochemistry, or closely related fields PhD with 2 years of experience, or Master’s with a minimum of 5 years experience in assay development for the life science industry, with demonstrated focus on epigenetic research KNOWLEDGE AND SKILLS: Expertise in liquid biopsy assay development is strongly preferred Experience in Next-Generation Sequencing (NGS) combined with hands-on experience in epigenetic techniques is a strong plus Extensive hands-on experience with nucleic acid techniques (DNA manipulation, PCR, qPCR, DNA quantitation/analysis, hybrid capture) Experience developing or executing assays using automated liquid handlers is preferred Must have experience performing data analysis with Excel (or JMP). Working knowledge of epigenetic analysis tools (Bismark, methylKit, or equivalent) is a plus Strong analytical and problem solving skills Skilled at cross-functional communication and coordination Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $116,800 — $146,000 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. WHAT WE OFFER Competitive Benefits - Employee benefits include comprehensive medical, dental, vision