Senior Associate Scientist, Biology

About Parabilis Medicines Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn . What’s the opportunity? The Senior Associate Scientist will play a hands-on role in discovery and translational biology, leading assay development and generating mechanistic insights to support oncology programs from lead optimization through biomarker development. This individual will partner cross-functionally to deliver high-quality, decision-driving data and contribute to advancing novel targets. Design, develop, and optimize multiplexed cell-based and high-throughput assays to ensure robust, reproducible, and scalable data generation Improve assay throughput and efficiency through automation or semi-automation, proactively identifying risks and refining experimental strategies Drive mechanistic understanding of novel oncology targets through hypothesis-driven experimentation (e.g., CRISPR, knockdown, tool compounds, rescue strategies) Integrate internal data, literature, and public datasets to inform experimental design, interpret results, and refine scientific hypotheses Contribute to biomarker discovery efforts and support translational strategy development Collaborate cross-functionally with chemistry, DMPK, in vivo pharmacology, and data science teams to advance programs from hit-to-lead through IND-enabling studies Support assay transfer to CROs, including data review, troubleshooting, and performance tracking Present findings clearly to project teams and maintain rigorous documentation, including ELN entries and SOP development What you’ll need to be successful: Education & Experience: Bachelor’s degree with 5+ years or Master’s degree with 4+ years of industry experience in a relevant field Experience in discovery biology, with exposure to oncology or related therapeutic areas preferred Technical Expertise: Strong hands-on experience developing and executing cell-based and high-throughput assays, including automation Quantitative approach to assay design and data quality (controls, reproducibility, robustness metrics) Experience designing and executing experiments independently and generating actionable insights from complex datasets Familiarity with a subset of the following: CRISPR/Cas9, gene editing/knockdown, overexpression systems qPCR/RT-qPCR, Western blotting, flow cytometry Reporter assays (e.g., luciferase, NanoBRET), protein–protein interaction assays Mammalian cell culture and functional assays (e.g., proliferation, apoptosis) High-throughput screening formats (e.g., 384-well) Omics approaches (e.g., RNA-seq, proteomics) preferred Automation platforms, ELN systems (e.g., Dotmatics), and SOP authorship Core Capabilities: Strong experimental rigor and data-driven decision-making Ability to manage multiple projects and priorities in a fast-paced environment Effective cross-functional collaboration and clear scientific communication Ownership mindset with ability to independently drive workstreams Demonstrated