Vice President, Development Data Science

About Parabilis Medicines Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact. For more information, visit www.parabilismed.com or follow us on LinkedIn . What’s the opportunity? The VP, Development Data Science will build and lead a cross functional data centric matrix to accelerate drug development, support regulatory submissions and guide the Real-World Data (RWD) / Real-World Evidence (RWE) function at Parabilis. This role is responsible for end-to-end strategy and execution of RWD/RWE and clinical data science to inform trial design, contextualize clinical results, support biomarker and translational work, and optimize site and patient selection. The VP will partner closely with Clinical Development, Clinical Operations, Biostatistics, Translational/Computational Biology, Regulatory, and the broader Data Science & Engineering team to maximize the probability of success of our clinical programs. Strategy & Leadership Define and own the Clinical Data Science strategy. Serve as the senior Clinical Data Science leader and primary point of contact for RWD/RWE across programs aligned with portfolio and corporate objectives. Represent Clinical Data Science on cross-functional governance and portfolio forums. RWD/RWE & Clinical Analytics Design and oversee RWE studies to contextualize clinical trials, including synthetic/external control arms, patient matching, and trial emulation. Use RWD to inform clinical trial design (eligibility criteria, endpoints, enrichment strategies), dose/regimen selection, and go/no-go decisions. Contribute data science insights for feasibility and site selection, including epidemiology, patient journeys, referral patterns, and diversity/access. Integrate RWD with internal clinical and biomarker data to support forward and reverse translation, target and indication strategy, and mechanism-of-resistance analyses. Establish and maintain best practices in causal inference, comparative effectiveness, and time-to-event modeling relevant to RWE in oncology. Data Assets, Partnerships & Infrastructure Identify, evaluate, and prioritize RWD sources (EHR, claims, registries, genomic/omic datasets, imaging, PROs) to support current and future clinical needs. Lead collaboration and contracting with RWD providers and academic/industry partners in coordination with Commercial, Business Development, Legal, and Procurement. Partner with Engineering and Data Science to define requirements for secure, scalable, compliant RWD infrastructure and analytic environments. Ensure data quality, interoperability, and governance suitable for regulatory-grade analyses. Team Building & Management Build and lead a high-performing Clinical Data Science team (e.g., RWE epidemiologists, clinical data scientists, etc). Set clear objectives, provide regular feedback, and support growth and succession planning. Foster a culture of scientific rigor, transparency, and effective collaboration with Clinical Development, Biostatistics, and other partners. Cross-Functional Collaboration & Communica