Scientist II, Assay Operations, Screening Platform Technologies

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a Scientist II, Assay Operations, Screening Platform Technologies (SPT) to support and scale next-generation cellular screening capabilities for oncology drug discovery. This role will focus on assay operations, screening execution, automation enablement, and assay scale-up to support high-throughput and high-content screening campaigns across early discovery and lead optimization programs. The successful candidate will partner closely with cross-functional collaborators across Discovery Sciences, Cancer Biology, Automation, Data Science, and external partners to establish robust, scalable, and operationally efficient screening workflows. This position is ideal for a scientist with strong experience executing and operationalizing cellular assays who enjoys working at the intersection of biology, automation, and screening infrastructure. In this role, you will support the transfer, optimization, execution, and scaling of cellular assays across multiple screening platforms, helping ensure assays are automation-ready, reproducible, and fit for high-throughput applications. You will contribute to the implementation of standardized workflows, assay quality control processes, instrumentation integration, and operational best practices that enable efficient data generation across internal and external screening activities. The ideal candidate is a highly collaborative and detail-oriented experimentalist with hands-on experience in assay operations, liquid handling automation, and screening logistics. They will thrive in a fast-paced environment, enjoy troubleshooting technical challenges, and contribute to building scalable screening infrastructure that accelerates oncology discovery efforts. Responsibilities Optimize, productionalize, validate, and execute robust screening assays across various cellular screening formats (e.g., CellTiter-Glo, NanoBRET, imaging-based, and transcriptomic readouts). Lead and support execution of high-throughput and medium-throughput screening campaigns using automated liquid handling and integrated instrumentation platforms. Coordinate assay transfer activities internally and externally, including protocol standardization, reagent qualification, documentation, and execution support. Develop and implement workflows for quantitative, scalable profiling in support of oncology programs. Contribute to experimental design discussions and data review for projects involving molecular glue characterization and protein interaction modulation. Apply advanced data analysis methods, integrating tools such as Genedata Screener, D360, Spotfire, and programming languages (Python, R) to derive actionable insights from complex assay outputs. Coordinate and manage tech transfer to external CROs, ensuring quality execution of high-throughput screens and phenotypic assays. Collaborate within SPT and across functions, Med Chem, Cancer Biology, Bioinformatics, Automation, to ensure cohesive project execution and data flow. Manage timelines and deliverables for multiple projects simultaneously, maintaining high standards for scientific rigor and project communication. Support training and mentorship of junior team members while contributing to the c