Director, Medical Information

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: We are seeking a motivated and experienced professional to join our team as a Director of Medical Information. This role focuses on ensuring the delivery of timely, accurate, and evidence-based responses to healthcare professionals (HCPs), patients, and caregivers. As a key member of the Medical Affairs team, you will oversee the creation and management of medical information content, support compendia and submissions, and contribute to AMCP dossier development and review. This role will also provide Medical Information support at scientific congresses and collaborate cross-functionally to support both pipeline assets and companion diagnostics. The ideal candidate is a skilled communicator with a strong scientific background and can manage projects in a dynamic environment. Key Responsibilities: Develops, reviews and maintains medical information resources such as standard response letters (SRLs), custom response letters (CRLs), FAQs and inquiry response guidance documents to support accurate and timely responses to customers. Manages unsolicited medical information inquiries and partners with the Medical Information call center vendor to ensure accurate, compliant, and timely responses. Ensures all medical information content is evidence-based, consistent, and aligned with the latest scientific and clinical data. Collaborates with Medical Affairs, Clinical Development, Market Access and other internal stakeholders to inform scientific communication, guideline strategy, and payer-facing materials. Supports NCCN guideline submission package development including submission planning and coordination across disease areas. Leads or contributes to the development, review and maintenance of AMCP dossiers to support market access and payer engagement strategies. Leads the development and execution of compendia submission process for Medical Affairs. Serves as Medical Reviewer in the Medical, Legal and Regulatory (MLR) process, ensuring that materials support evidence-based communication and comply with company policies, industry standards, and regulatory requirements. Collaborates with cross-functional partners to provide strategic medical insights and ensure scientific accuracy in promotional and non-promotional materials. Provides medical information and scientific support related to companion diagnostics associated with therapeutic assets, ensuring aligned communication across stakeholders. Provides Medical Information support for congresses, including staffing Medical Information booths and responding to HCP inquiries. Leads the development and maintenance of internal SOPs and processes to ensure compliance with regulatory requirements and industry standards. Demonstrated success leading cross-functional medical information strategies that influence scientific communication, market access, and global readiness. Monitors relevant scientific publications and clinical trial data to inform medical information content and strategy. Provides support for other Medical Affairs projects as needed. Required Skills, Experience and Education: Advanced degree in scientific or medical discipline; doctoral degree preferred (PharmD, MD, PhD) with 11+ years of experience. Proven exper