Director, Global Medical Excellence

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a Director, Global Medical Excellence, supporting the European region to serve as a key scientific and strategic partner to the Head of Global Medical Excellence. This role will help integrate and advance Medical Excellence initiatives across the portfolio for the European region by connecting science, strategy, and execution across the European regional Medical Affairs teams, in collaboration with the global teams. Key Responsibilities Serve as a scientific thought partner to the Head of Global Medical Excellence, helping translate medical strategy into aligned Medical Excellence priorities. Connect and integrate scientific themes, data narratives, and strategic objectives across Medical Excellence functions (e.g., publications, content & training, stakeholder engagement, analytics). Support consistency and quality of scientific messaging and execution across global and regional Medical Affairs activities. Global–Regional Medical Partnership Act as a key liaison between Global Medical Excellence and regional/local European Medical Affairs teams. Facilitate bidirectional communication to ensure regional perspectives, needs, and insights inform global and European-specific Medical Excellence initiatives. Support alignment of global frameworks with European regional execution realities, particularly around congresses, scientific exchange, and launch readiness. Medical Excellence Leadership Support Support agenda setting, scientific framing, and follow-up for Medical Excellence leadership forums and key cross-functional discussions. Help identify priorities, risks, and opportunities across Medical Excellence initiatives and proactively surface insights to leadership. Prepare scientific briefings, strategic summaries, and leadership materials that enable effective decision-making. Scientific Quality, Governance & Continuous Improvement Partner with Medical Governance to support scientific rigor, compliance, and quality standards across Medical Excellence activities. Contribute to evolution of Medical Excellence ways of working, ensuring they remain science-driven, fit-for-purpose, and scalable. Identify opportunities to enhance integration, reduce silos, and strengthen scientific impact across Medical Affairs capabilities. Digital & Systems Projects: Support digital transformation initiatives within Medical Affairs, including the implementation and optimization of medical systems, databases, and reporting tools. Identify and deploy technology solutions that enhance efficiency, data management, and cross-functional collaboration. Ensure seamless integration of digital tools to support Medical Affairs functions, including grants management, medical communications and insights tracking. Cross-Functional Collaboration Collaborate closely with Global Medical Strategy, Medical Communications/Publications, Medical Information, Analytics & Insights, Stakeholder Engagement, and European Regional Medical Affairs. Engage with Clinical Development, HEOR, Patient Advocacy, and Commercial (as appropriate) to ensure aligned scientific narratives, coordinated operations and compliant collaboration. Serve as a connector across teams, fostering a culture