Director, Global Medical Affairs – GI Oncology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Director, Global Medical Affairs will report to the GI Tumors Medical Affairs Strategy Lead and will be responsible for supporting the development and execution of the Global Medical Affairs (GMA) strategy and tactical plans for Revolution Medicines assets being developed for the treatment of GI cancers, with a focus on PDAC and CRC. Key aspects of this role include the following: support the development and execution of a Healthcare Professional (HCP) engagement strategy to gather insights that shape internal programs; act as the medical representative on cross-functional teams; serve as a therapeutic area content expert; and support medical affairs functions as needed. As a member of the GMA team, the successful candidate will participate in the Global Medical Affairs Team (GMAT) to execute medical strategies, contribute to the operations and oversight of medical activities, and work cross-functionally to support associated pre-launch activities. This role is an essential member of the Medical Affairs team who will work as an extension of the GMA organization, collaborating with stakeholders across the organization, including, but not limited to, Clinical Development and Operations, Commercial Operations, Program Management, Business Development, Regulatory, Safety, and Compliance teams. The ideal candidate is an effective communicator, entrepreneurial, detail-oriented, proactive, scientifically driven, a skilled collaborator, and able to build compelling scientific narratives and effectively implement medical tactics aligned with the Medical Affairs plans. Key responsibilities: Lead the development and execution of the GMA strategy and medical objectives as part launch readiness/launch execution, including activities related to scientific engagement and communication, evidence generation, internal education, and patient advocacy. Coordinates the execution of routine gap assessments leading to the development and refinement of a publication strategy, evidence generation plan, and tactical plan as part of the overall GMA plan. Provides medical support in scientific engagement activities with key external stakeholders through organizing and participating in advisory boards, study investigator interactions, congress activities, and peer-to-peer discussions, communicating scientific insights to internal teams to help drive strategy. Communicates clinical and scientific data to KOLs and other healthcare professionals through presentations, educational programs, and scientific discussions. Represents medical affairs functions in cross-functional strategy team meetings, including Clinical and Safety sub-teams, Global Brand Team, Global Product Team, Patient Advocacy, Market Access, and other cross-functional strategic discussions. Participates in the Global Medical Affairs Team (GMAT) to execute medical strategies, contribute to the operations and oversight of medical activities, and work cross-functionally to support associated pre-launch activities. Partners with RWE strategy and Biomarker/CDx teams on integrated evidence generation strategies and activities as part of the GMA Plan. Works with the Patient Advocacy and Grants teams to incorporate the patient voice