Vice President, Business Systems, Central Technology

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to harness the power of technology to pursue some of society’s most ambitious goals — from curing or preventing all disease to transforming how students learn. At CZI, you’ll join a deeply collaborative, mission-driven community where your work helps drive breakthroughs across our flagship nonprofit organizations, Biohub and Learning Commons. Whether enabling scientific breakthroughs via open science and AI-powered biology or strengthening the tools teachers and students rely on every day, your contributions help turn bold ideas into real-world impact. Our teams operate at the intersection of innovation and scale, building the infrastructure, partnerships, and capabilities that allow scientists, educators, and innovators to tackle some of the most complex challenges of our time — and to do so with urgency, integrity, and optimism. The Team The Operations team is a key partner in enabling Biohub’s pioneering work to combine frontier AI with frontier biology to solve disease and Learning Commons’ mission to build AI infrastructure that aligns how students learn with the tools that shape their learning experiences. Operations includes our Central Tech, Finance, Marketing & Communications, People, and Real Estate / Workplace / Events / Facilities / Security (REWFS) teams. Together, these teams create the systems, programs, and experiences that empower our partners and colleagues across Biohub and Learning Commons to drive impact. This work requires strategic and operational rigor, creativity, and deep collaboration. Whether designing world-class employee experiences, safeguarding data and infrastructure, or shaping how we communicate our impact, Operations plays a critical role in helping deliver meaningful change at scale. The Opportunity The Vice President of Business Systems will serve as the executive leader responsible for the product vision, strategy, governance, and execution of CZI’s enterprise platforms across Finance, People, Grants, Contracts (Legal), and Brand & Communications. This role is accountable for evolving CZI’s systems ecosystem from distributed, domain-specific tools into cohesive, product-driven, mission-aligned platforms. Success requires moving beyond system administration or vendor-led implementations to design intuitive, end-to-end user experiences, reduce operational friction, and enable clear, data-driven decision-making across the organization. As a key member of Central Technology’s leadership team, reporting to the Senior Vice President of Central Technology, the Vice President of Business Systems will shape organizational strategy, strengthen cross-functional collaboration at scale, and build a world-class internal tools organization. This leader will treat business systems as internal products, emphasizing product excellence, reliability, and seamless user experience to transform how a complex, mission-driven organization operates at every level. What You'll Do Define and own the product vision and multi-year strategy for business systems, ensuring internal platforms are designed around real user needs and aligned with CZI’s organizational priorities. Lead the evolution of Business Systems into a product-led internal tools organization, with clear product ownership, discovery practices, prioritization frameworks, and roadmap discipline. Treat enterprise platforms (e.g., Workday, Salesforce, Coupa, Greenhouse, Ironclad) as foundational infrastructure, designing cohesive workflows and user experiences on top of them rather than relying solely on out-of-the-box functionality. Build, lead, and mentor a high-performing, multidisciplinary team spanning product, program management, engineering, analytics, and systems leadership. Establish governance frameworks and cross-functional decision-making models that support product strategy, tradeoff clarity, and long-term platform health across Finance, People, Grants, Con