Director of Facilities and Laboratory Operations

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER+/HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential. Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond . You can view our latest corporate deck and other presentations here . About the Role >>> Director of Facilities and Laboratory Operations As the Director of Facilities, Laboratory Operations reporting to the VP of IT, Real Estate, and Facilities Lab Operations, you will play a critical leadership role in shaping and scaling the environments that power Olema’s science and innovation. You will lead the strategy, operations, and long-term planning for Olema’s facilities and laboratory infrastructure across multiple sites, ensuring our spaces evolve alongside the company’s ambitious growth trajectory. In this role, you will own the full lifecycle of facilities and laboratory operations — from driving day-to-day operational excellence to leading complex, high-impact initiatives including laboratory buildouts, expansions, and office and lab relocations. You will oversee three Olema locations spanning BSL-2 laboratory environments and corporate office space, creating safe, efficient, and collaborative environments where teams can do their best work. As a trusted cross-functional partner to Research, IT, Real Estate, Finance and Executive Leadership, you will help build the operational foundation that enables Olema to scale with agility, support groundbreaking science, and foster a culture of innovation, safety, and continuous improvement. This role is based in our San Francisco office and will require 15% travel. Your work will primarily encompass: Facilities, Real Estate & Capital Execution Lead and execute all facilities operations and physical infrastructure activities across Olema’s locations Own the execution of Real Estate strategy, including site readiness, lease transitions, expansions, consolidations, and exits Lead office and laboratory moves and building relocations, with full accountability for planning, execution, risk management, and stabilization Direct laboratory and office buildouts end-to-end, from programming and design through permitting, construction, commissioning, and occupancy Execute capital projects in active lab environments while maintaining safety, compliance, and continuity of scientific operations Develop and enforce facilities standards, policies, procedures, and SOPs Own physical security programs, including access control, badging, alarms, vendor oversight, and incident response Control facilities operating and capital budgets, including forecasting, spend management, and cost accountability Lead emergency planning and response across all facilities Direct shipping and receiving operations, including Hazardous Materials and Dangerous Goods compliance Own all workplace services across all locations, including office supplies, beverage and food programs, janitorial services, and waste management, with accountability for vendor performance, cost control, and service quality Laboratory Operations Support the research team with all infrastructure needs, including vendor relationships and management, service and maintenance of scientific equipment, hazardous waste management, and cell culture support Monitor critical systems and provide 24-hour on-call support in case of system failure Develop and maintain awarene