Senior Director, US Market Access

MISSION Mirum Pharmaceuticals is a biopharmaceutical company dedicated to transforming the treatment of rare diseases. We are passionate about advancing scientific discoveries to become important medicines for rare disease patients. We are collaborative, creative, and experienced professionals and we’re looking to augment our team with other individuals who embody our values: care, be real, get it done, and have fun, seriously. POSITION SUMMARY Mirum Pharmaceuticals is a rare disease company with a growing portfolio of innovative therapies and a robust pipeline, Mirum is committed to improving the lives of patients who often face limited treatment options and complex care journeys. We operate with a deep sense of purpose and urgency—grounded in our values: Care. Have Fun. Be Real. Get it Done. As we continue to scale, market access plays a critical role in ensuring that innovation translates into real-world patient access. The Senior Director of U.S. Market Access will: Shape and elevate U.S. market access strategy to drive optimal coverage, pricing, and patient access across the existing portfolio and future assets. Lead critical access decisions end-to-end—owning pricing strategy, payer positioning, and execution with a high degree of autonomy. Challenge the status quo by introducing differentiated, insight-driven approaches rooted in real-world payer dynamics and behavior. This role is highly cross-functional and enterprise-facing, partnering across Commercial, Medical, Patient Services (HUB), Government Pricing, Legal/Compliance, and Supply Chain to shape and deliver meaningful access strategies. The ideal candidate blends strategic vision with operational experience, bringing deep payer expertise and a passion for rare disease patients. JOB FUNCTIONS/RESPONSIBILITIES Lead the development of market access strategies that drive coverage expansion, policy optimization, and quality of access (QOA) improvements across commercial and government payers for inline and pipeline assets Identify key differentiators critical to payers for rare disease products in competitive environments and translate into actionable strategy Anticipate and shape payer dynamics in rare disease to craft clear, differentiated value narratives that resonate in competitive rare disease markets (UM criteria, specialty pharmacy distribution, generics/biosimilar pressure) for both in-line and pipeline assets Translate clinical and economic evidence into practical, payer-ready tools that influence coverage and reimbursement decisions Lead pre-launch payer engagement, value evidence planning, and access readiness to ensure optimal coverage pathways, especially in competitive markets Partner cross-functionally with medical and marketing to ensure evidence generation is targeted, efficient, and directly aligned to access impact. Engage directly with payer stakeholders to uncover actionable insights and convert them into strategic access decisions Align with the US Head of Payer Accounts on strategic account planning and escalation for high-impact access challenges Act as the enterprise voice of access, influencing key decisions across brand strategy, pricing, and commercialization planning workstreams Collaborate with Government Pricing on policy implications (e.g., Medicaid best price, 340B, IRA/GUARD considerations) Ensure compliance with all regulatory and legal requirements QUALIFICATIONS Education /Experience: Bachelor’s degree required; MBA or advanced degree preferred 10+ years of experience in market access, payer marketing, or reimbursement, with rare disease experience strongly preferred Proven success in launching and optimizing access for specialty/rare disease therapies, including pricing strategy Deep understanding of: Commercial and government payer dynamics Prior authorization, appeals, and reimbursement pathways Successful experience in leading and developing a team within the market access function Demonstrated ability to lead cross-functional