Senior Director, HEOR – Acoramidis (Global Lead)

Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work. What You'll Do BridgeBio is seeking a highly strategic and execution-oriented HEOR leader to define and drive the global evidence strategy for acoramidis in ATTR-CM. This individual will play a pivotal role in enabling successful global launch, optimizing payer access, and sustaining long-term product differentiation in an increasingly competitive and evolving landscape. As the global HEOR lead, this role will shape the evidence generation agenda across the product lifecycle—spanning clinical development, launch, and post-marketing—leveraging real-world evidence (RWE), comparative effectiveness research, and patient-centered outcomes. The leader will serve as a key partner to Market Access, Medical Affairs, Clinical Development, and Commercial teams to ensure evidence translates into impactful value narratives for payers and HTA bodies worldwide. Why This Role Matters Acoramidis represents a transformative opportunity in ATTR-CM. This role is central to articulating and proving its value to patients, providers, and payers globally. By shaping the evidence strategy and driving impactful insights, this leader will directly influence access, adoption, and long-term success in a competitive and rapidly evolving therapeutic area. Key Responsibilities Global HEOR Strategy: Define and lead the end-to-end global HEOR strategy for acoramidis across launch and lifecycle, ensuring alignment with clinical, regulatory, and commercial objectives and driving evidence-based decision-making Evidence Generation & Data Strategy: Design and oversee innovative real-world evidence (RWE), economic models, and data partnerships (e.g., claims, EHR, observational survey datasets) to support value demonstration and long-term evidence generation Payer & HTA Readiness: Develop robust, payer-relevant evidence packages and lead HEOR contributions to global HTA submissions, pricing, reimbursement, and access strategies Publications & Scientific Dissemination: Lead the HEOR publication strategy, including congress planning and peer-reviewed publications with Pubs teams, to establish a compelling and credible evidence narrative Patient-Centered Outcomes: Drive the development and integration of PROs and other patient-centered endpoints to demonstrate meaningful clinical benefit and differentiation Competitive Intelligence & Positioning: Proactively assess and anticipate competitive dynamics (including generics, pipeline entrants, and alternative therapies) to inform evidence strategy and positioning Cross-Functional Leadership: Partner closely with Market Access, Medical Affairs, Clinical, Regulatory, and Commercial teams to ensure cohesive and actionable evidence strategies Governance & Scientific Integrity: Ensure HEOR activities are conducted with scientific rigor and appropriate governance, maintaining independence of evidence generation while enabling compliant, impactful use External Engagement: Oversee external vendors, research partners, and